When I get my sinus headaches I reach for 3 ibuprofen. Here is a copy and paste from a google search:
"Ibuprofen and other NSAIDS rarely affect the liver. Unlike acetaminophen (Tylenol) most NSAIDs are absorbed completely and have negligible first-pass hepatic (liver) metabolism. In other words, the way NSAIDS are metabolized makes liver toxicity (hepatotoxicity) very rare."
Thanks. This quote motivated me to re-research why I had recalled long term medical risks from NSAID's like ibuprofen and naproxen that were greater than the risks from acetaminophen, especially for older folks. It isn't damage to the liver, but damage to other important organs such as the stomach, kidneys, heart and brain.
HERE is a peer reviewed research paper from the National Institutes of Health website, which summarizes its conclusions as follows:
"Studies of older adults show that chronic NSAID use increases the risk of peptic ulcer disease, acute renal failure, and stroke/myocardial infarction. Moreover, chronic NSAID use can exacerbate a number of chronic diseases including heart failure and hypertension, and can interact with a number of drugs (eg, warfarin, corticosteroids). Preferred analgesics in older adults that may have a lower risk of these adverse drug reactions include acetaminophen, a nonacetylated salicylate (eg, salsalate), a short half-life NSAID (eg, ibuprofen), or low-dose opioid/opioid-like agents in combination with acetaminophen (in appropriate patients)."